Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy

被引：218

作者：

Du, Jin-Zhi ^{[1
]}

Mao, Cheng-Qiong ^{[2
,3
]}

Yuan, You-Yong ^{[2
,3
]}

Yang, Xian-Zhu ^{[2
,3
]}

Wang, Jun ^{[2
,3
]}

机构：

[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

来源：

BIOTECHNOLOGY ADVANCES | 2014年 / 32卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Nanoparticles; Cancer therapy; Drug delivery; Surface charge reversal; Tumor extracellular acidity responsive; BLOCK-COPOLYMER MICELLES; POLYMERIC MICELLE; MULTIDRUG-RESISTANCE; BREAST-CANCER; IN-VIVO; TARGETED NANOPARTICLES; SOLID TUMORS; MACROMOLECULAR THERAPEUTICS; GOLD NANOPARTICLES; RNAI THERAPEUTICS;

D O I：

10.1016/j.biotechadv.2013.08.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

pH-responsive nanoparticles (NPs) are currently under intense development as drug delivery systems for cancer therapy. Among various pH-responsiveness, NPs that are designed to target slightly acidic extracellular pH environment (pH(e)) of solid tumors provide a new paradigm of tumor targeted drug delivery. Compared to conventional specific surface targeting approaches, the pH(e)-targeting strategy is considered to be more general due to the common occurrence of acidic microenvironment in solid tumors. This review mainly focuses on the design and applications of pH(e)-activated NPs, with special emphasis on pH(e)-activated surface charge reversal NPs, for drug and siRNA delivery to tumors. The novel development of NPs described here offers great potential for achieving better therapeutic effects in cancer treatment. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：789 / 803

页数：15

共 96 条

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