HLA-DR and the development of rheumatoid arthritis

被引：20

作者：

Auger, I ^{[1
]}

Roudier, J ^{[1
]}

机构：

[1] FAC MED,LAB IMMUNORHUMATOL,F-13005 MARSEILLE,FRANCE

来源：

AUTOIMMUNITY | 1997年 / 26卷 / 02期

关键词：

rheumatoid arthritis; HLA-DR; shared epitope; T cell repertoire; 70 kD heat shock proteins;

D O I：

10.3109/08916939709003856

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Susceptibility to develop Rheumatoid arthritis (RA) maps to a highly conserved amino acid motif (''the shared epitope'') expressed in the third hypervariable region of different HLA-DRB1 alleles. This motif, namely QKRAA, QRRAA or RRRAA helps the development of RA by an unknown mechanism. However, it is now established that the shared epitope can 1/Shape the T cell repertoire 2/Interact with 70 kD heat shock proteins.

引用

收藏

页码：123 / 128

页数：6

相关论文

共 17 条

[1] A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis [J].

Albani, S ;

Carson, DA .

IMMUNOLOGY TODAY, 1996, 17 (10) :466-470

[2] MOLECULAR-BASIS FOR THE ASSOCIATION BETWEEN HLA DR4 AND RHEUMATOID-ARTHRITIS - FROM THE SHARED EPITOPE HYPOTHESIS TO A PEPTIDIC MODEL OF RHEUMATOID-ARTHRITIS [J].

ALBANI, S ;

ROUDIER, J .

CLINICAL BIOCHEMISTRY, 1992, 25 (03) :209-212

[3] THE SUSCEPTIBILITY SEQUENCE TO RHEUMATOID-ARTHRITIS IS A CROSS-REACTIVE B-CELL EPITOPE SHARED BY THE ESCHERICHIA-COLI HEAT-SHOCK PROTEIN DNAJ AND THE HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN DRB10401 MOLECULE [J].

ALBANI, S ;

TUCKWELL, JE ;

ESPARZA, L ;

CARSON, DA ;

ROUDIER, J .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (01) :327-331

[4]

AUGER L, 1996, NAT MED, V3, P306

[5] Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen [J].

Fugger, L ;

Rothbard, JB ;

SonderstrupMcDevitt, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :928-933

[6] An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex [J].

Garcia, K. Christopher ;

Degano, Massimo ;

Stanfield, Robyn L. ;

Brunmark, Anders ;

Jackson, Michael R. ;

Peterson, Per A. ;

Teyton, Luc ;

Wilson, Ian A. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (11) :209-219

[7] THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].

GREGERSEN, PK ;

SILVER, J ;

WINCHESTER, RJ .

ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213

[8]

OLLIER W, 1992, RHEUM DIS CLIN N AM, V18, P741

[9] Molecular mimicry reflected through database screening: Serendipity or survival strategy? [J].

Roudier, C ;

Auger, I ;

Roudier, J .

IMMUNOLOGY TODAY, 1996, 17 (08) :357-358

[10] THE EPSTEIN-BARR VIRUS GLYCOPROTEIN GP110, A MOLECULAR LINK BETWEEN HLA-DR4, HLA-DR1, AND RHEUMATOID-ARTHRITIS [J].

ROUDIER, J ;

RHODES, G ;

PETERSEN, J ;

VAUGHAN, JH ;

CARSON, DA .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 27 (04) :367-371