Dendritic cells and autoimmunity

被引：35

作者：

Bayry, J

Thirion, M

Delignat, S

Misra, N

Lacroix-Desmazes, S

Kazatchkine, MD

Kaveri, SV

机构：

[1] INSERM, U430, F-75006 Paris, France

[2] Univ Paris 06, Inst Cordeliers, Paris, France

来源：

AUTOIMMUNITY REVIEWS | 2004年 / 3卷 / 03期

关键词：

dendritic cells; autoimmunity; immunotherapy; tolerogenicity;

D O I：

10.1016/S1568-9972(03)00104-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for DC in initiating autoimmune attacks. Direct analysis of DC phenotypes and DC T cell interactions in rodent and human autoimmune diseases souls shed light on how pathogenesis occurs, and suggest novel avenues of treatment aimed at alleviating deviant DC function. (C) 2003 Elsevier B.V. All rights reserved.

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收藏

页码：183 / 187

页数：5

相关论文

共 40 条

[1] The control of T cell activation vs. tolerance [J].

Abbas, AK .

AUTOIMMUNITY REVIEWS, 2003, 2 (03) :115-118

[2] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[3] Intravenous immunoglobulin abrogates dendritic cell differentiation induced by interferon-α present in serum from patients with systemic lupus erythematosus [J].

Bayry, J ;

Lacroix-Desmazes, S ;

Delignat, S ;

Mouthon, L ;

Weill, B ;

Kazatchkine, MD ;

Kaveri, SV .

ARTHRITIS AND RHEUMATISM, 2003, 48 (12) :3497-3502

[4] Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin [J].

Bayry, J ;

Lacroix-Desmazes, S ;

Carbonneil, C ;

Misra, N ;

Donkova, V ;

Pashov, A ;

Chevailler, A ;

Mouthon, L ;

Weill, B ;

Bruneval, P ;

Kazatchkine, MD ;

Kaveri, SV .

BLOOD, 2003, 101 (02) :758-765

[5]

Binks M, 1998, EUR J IMMUNOL, V28, P3259

[6] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[7] Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-κB oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig [J].

Bonham, CA ;

Peng, LS ;

Liang, XY ;

Chen, ZY ;

Wang, LF ;

Ma, LL ;

Hackstein, H ;

Robbins, PD ;

Thomson, AW ;

Fung, JJ ;

Qian, SG ;

Lu, L .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3382-3391

[8] Origin, maturation and antigen presenting function of dendritic cells [J].

Cella, M ;

Sallusto, F ;

Lanzavecchia, A .

CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (01) :10-16

[9] Vaccine-induced autoimmunity [J].

Cohen, AD ;

Shoenfeld, Y .

JOURNAL OF AUTOIMMUNITY, 1996, 9 (06) :699-703

[10]

Dittel BN, 1999, J IMMUNOL, V163, P32

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