The total synthesis of (+)-dragmacidin F

被引：143

作者：

Garg, NK ^{[1
]}

Caspi, DD ^{[1
]}

Stoltz, BM ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 31期

关键词：

D O I：

10.1021/ja046695b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of (+)-dragmacidin F has been accomplished, establishing the absolute configuration of this biologically important, antiviral marine alkaloid. The convergent route described features a palladium-mediated oxidative pyrrole carbocylization reaction to construct the [3.3.1] bicycle, as well as a highly selective Suzuki coupling to build the carbon skeleton of the natural product. A late-stage Neber rearrangement allows for the facile installation of the aminoimidazole moiety to provide (+)-dragmacidin F. Copyright © 2004 American Chemical Society.

引用

页码：9552 / 9553

页数：2

共 24 条

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