The effects of diets enriched in beta-glucans on blood lipoprotein concentrations

被引:46
作者
Chen, Jiezhong [1 ]
Huang, Xu-Feng [1 ]
机构
[1] Univ Wollongong, Sch Hlth Sci, Wollongong, NSW 2522, Australia
关键词
Beta-glucans; Lipoprotein; Cholesterol; CYP7A1; CYP3A4; Bile acids; LDLR; BILE-ACID SYNTHESIS; HYPERCHOLESTEROLEMIC SUBJECTS; CHOLESTEROL CONCENTRATIONS; NUCLEAR RECEPTORS; HUMAN LIVER; OAT; BARLEY; METABOLISM; MICE; OLIGOSACCHARIDES;
D O I
10.1016/j.jacl.2009.04.054
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Dietary beta-glucans lower the blood concentrations of cholesterol in animals and humans. Recent studies have uncovered mechanisms by which dietary beta-glucans may regulate cholesterol homeostasis. There is evidence that beta-glucans sequester bile acids in the intestine, reducing their reabsorption and return to the liver. Reducing hepatic bile acid concentrations activates the enzyme CYP7A1, which converts cholesterol into bile acids. This action leads to a reduction of hepatic cell cholesterol content, which up-regulates low-density lipoprotein (LDL) receptor synthesis and thereby accelerates the transportation of LDL-cholesterol from the blood into hepatocytes. Reduced intracellular cholesterol also up-regulates the hepatic synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and could therefore provide an additive effect in suppressing hepatocyte cholesterol to that produced by enhancing its depletion with beta-glucans. Through this combination of agents, one would expect a greater clearance of LDL from the plasma with lower steady state levels of LDL-cholesterol. (C) 2009 National Lipid Association. All rights reserved.
引用
收藏
页码:154 / 158
页数:5
相关论文
共 38 条
[1]   Feedback regulation of bile acid synthesis in human liver:: Importance of HNF-4α for regulation of CYP7A1 [J].
Abrahamsson, A ;
Gustafsson, U ;
Ellis, E ;
Nilsson, LM ;
Sahlin, S ;
Björkhem, I ;
Einarsson, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (02) :395-399
[2]   Issues surrounding health claims for barley [J].
Ames, Nancy P. ;
Rhymer, Camille R. .
JOURNAL OF NUTRITION, 2008, 138 (06) :1237S-1243S
[3]  
[Anonymous], 1996, FED REG, V61, P296
[4]  
Brown L, 1999, AM J CLIN NUTR, V69, P30
[5]   Oat: unique among the cereals [J].
Butt, Masood Sadiq ;
Tahir-Nadeem, Muhammad ;
Khan, Muhammad Kashif Iqbal ;
Shabir, Rabia ;
Butt, Mehmood S. .
EUROPEAN JOURNAL OF NUTRITION, 2008, 47 (02) :68-79
[6]   Medicinal importance of fungal β-(1→3), (1→6)-glucans [J].
Chen, Jiezhony ;
Seviour, Robert .
MYCOLOGICAL RESEARCH, 2007, 111 :635-652
[7]   Nuclear receptors, bile-acid detoxification, and cholestasis [J].
Chen, JZ ;
Raymond, K .
LANCET, 2006, 367 (9509) :454-456
[8]   Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms [J].
Chiang, JYL .
JOURNAL OF HEPATOLOGY, 2004, 40 (03) :539-551
[9]   Novel Nonstatin Strategies to Lower Low-Density Lipoprotein Cholesterol [J].
Davidson, Michael H. .
CURRENT ATHEROSCLEROSIS REPORTS, 2009, 11 (01) :67-70
[10]   Hypercholesterolemia Treatment Patterns and Low-Density Lipoprotein Cholesterol Monitoring in Patients with a Diagnosis of Atherosclerosis in Clinical Practice [J].
Davidson, Michael H. ;
Gandhi, Sanjay K. ;
Ohsfeldt, Robert L. ;
Fox, Kathleen M. .
AMERICAN JOURNAL OF MEDICINE, 2009, 122 (01) :S51-S59