Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

被引:117
作者
Benekli, Mustafa
Baumann, Heinz
Wetzler, Meir [1 ]
机构
[1] Roswell Pk Canc Inst, Dept Med, Leukemia Sect, Buffalo, NY 14263 USA
关键词
ACUTE MYELOID-LEUKEMIA; TYROSINE KINASE INHIBITOR; COLONY-STIMULATING FACTOR; RETINOIC ACID RECEPTOR; DNA-BINDING ACTIVITY; CELL-CYCLE ARREST; CONSTITUTIVE ACTIVATION; ARSENIC TRIOXIDE; STAT PROTEINS; FUSION PROTEIN;
D O I
10.1200/JCO.2008.21.3264
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Signal transducer and activator of transcription (STAT) proteins comprise a seven-member family of latent cytoplasmic transcription factors that are activated through tyrosine phosphorylation by a variety of cytokines and growth factors. Aberrant activation of STATs accompanies malignant cellular transformation with resultant leukemogenesis. Constitutive activation of STATs has been demonstrated in various leukemias. A better understanding of the mechanisms of dysregulation of the STAT pathway and understanding of the cause and effect relationship in leukemogenesis may serve as a basis for designing novel therapeutic strategies directed against STATs. Mechanisms of STAT activation, the potential role of STAT signaling in leukemogenesis, and recent advances in drug discovery targeting the STAT pathway are the focus of this review.
引用
收藏
页码:4422 / 4432
页数:11
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