Self-assembly of fibers and fibrils

被引：54

作者：

Binder, Wolfgang H.

Smrzka, Oskar W.

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] St Anna Kinderkrebsforsch, Childrens Canc Res Inst, A-1090 Vienna, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期

关键词：

Alzheimer's disease; fibrous proteins; gelators; peptides; self-assembly;

D O I：

10.1002/anie.200602001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein-folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：7324 / 7328

页数：5

相关论文

共 75 条

[1]

Abdallah DJ, 2000, ADV MATER, V12, P1237

[2] Practical assay and molecular mechanism of aggregation inhibitors of β-amyloid [J].

Akikusa, S ;

Nakamura, K ;

Watanabe, KI ;

Horikawa, E ;

Konakahara, T ;

Kodaka, M ;

Okuno, H .

JOURNAL OF PEPTIDE RESEARCH, 2003, 61 (01) :1-6

[3]

Avrami M., 1940, J CHEM PHYS, V8, P212, DOI [10.1063/1.1750631, DOI 10.1063/1.1750631]

[4] Analysis of the structural and functional elements of the minimal active fragment of islet amyloid polypeptide (IAPP) - An experimental support for the key role of the phenylalanine residue in amyloid formation [J].

Azriel, R ;

Gazit, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :34156-34161

[5] Amyloid formation modulates the biological activity of a bacterial protein [J].

Bieler, S ;

Estrada, L ;

Lagos, R ;

Baeza, M ;

Castilla, J ;

Soto, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26880-26885

[6] 'Nature-inspired' drug-protein complexes as inhibitors of Aβ aggregation [J].

Bose, M ;

Gestwicki, JE ;

Devasthali, V ;

Crabtree, GR ;

Graef, IA .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :543-547

[7] Affinity-based inhibition of β-amyloid toxicity [J].

Cairo, CW ;

Strzelec, A ;

Murphy, RM ;

Kiessling, LL .

BIOCHEMISTRY, 2002, 41 (27) :8620-8629

[8] Protofibril formation of amyloid β-protein at low pH via a non-cooperative elongation mechanism [J].

Carrotta, R ;

Manno, M ;

Bulone, D ;

Martorana, V ;

San Biagio, PL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (34) :30001-30008

[9] Mass spectrometry-based screening for inhibitors of β-amyloid protein aggregation [J].

Cheng, X ;

van Breemen, RB .

ANALYTICAL CHEMISTRY, 2005, 77 (21) :7012-7015

[10] Designing conditions for in vitro formation of amyloid protofilaments and fibrils [J].

Chiti, F ;

Webster, P ;

Taddei, N ;

Clark, A ;

Stefani, M ;

Ramponi, G ;

Dobson, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3590-3594

← 1 2 3 4 5 6 7 8 →