Self-assembly of fibers and fibrils

被引：54

作者：

Binder, Wolfgang H.

Smrzka, Oskar W.

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] St Anna Kinderkrebsforsch, Childrens Canc Res Inst, A-1090 Vienna, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期

关键词：

Alzheimer's disease; fibrous proteins; gelators; peptides; self-assembly;

D O I：

10.1002/anie.200602001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein-folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：7324 / 7328

页数：5

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