Self-assembly of fibers and fibrils

被引：54

作者：

Binder, Wolfgang H.

Smrzka, Oskar W.

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] St Anna Kinderkrebsforsch, Childrens Canc Res Inst, A-1090 Vienna, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期

关键词：

Alzheimer's disease; fibrous proteins; gelators; peptides; self-assembly;

D O I：

10.1002/anie.200602001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein-folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7324 / 7328

页数：5

共 75 条

[61] Folding proteins in fatal ways [J].

Selkoe, DJ .

NATURE, 2003, 426 (6968) :900-904

[62]

Smith LA, 2004, COLLOID SURFACE B, V39, P125, DOI [10.1016/j.colsurfb.2003.12.004, 10.1016/j.colsurfb.2003.l2.004]

[63] Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates [J].

Söderberg, L ;

Dahlqvist, C ;

Kakuyama, H ;

Thyberg, J ;

Ito, A ;

Winblad, B ;

Näslund, J ;

Tjernberg, LO .

FEBS JOURNAL, 2005, 272 (09) :2231-2236

[64] Low molecular mass gelators of organic liquids and the properties of their gels [J].

Terech, P ;

Weiss, RG .

CHEMICAL REVIEWS, 1997, 97 (08) :3133-3159

[65] Emerging ideas on the molecular basis of protein and peptide aggregation [J].

Thirumalai, D ;

Klimov, DK ;

Dima, RI .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2003, 13 (02) :146-159

[66] The 3D profile method for identifying fibril-forming segments of proteins [J].

Thompson, MJ ;

Sievers, SA ;

Karanicolas, J ;

Ivanova, MI ;

Baker, D ;

Eisenberg, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (11) :4074-4078

[67] Using budding yeast to screen for anti-prion drugs [J].

C.N.R.S. UMR7150, Amyloids and Cell Division Cycle Laboratory, Station Biologique, Roscoff, Bretagne, France ;

不详 ;

不详 .

Biotechnol. J., 2006, 1 (58-67)

[68] Progress towards a molecular-level structural understanding of amyloid fibrils [J].

Tycko, R .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (01) :96-103

[69]

van Bommel K. J. C., 2004, ANGEW CHEM, V116, P1695, DOI [10.1002/ange.200352396, DOI 10.1002/ANGE.200352396]

[70] Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture [J].

van Bommel, KJC ;

van der Pol, C ;

Muizebelt, I ;

Friggeri, A ;

Heeres, A ;

Meetsma, A ;

Feringa, BL ;

van Esch, J .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (13) :1663-1667

← 1 2 3 4 5 6 7 8 →