Ugi multicomponent reaction with hydroxylamines: an efficient route to hydroxamic acid derivatives

被引：32

作者：

Basso, A ^{[1
]}

Banfi, L ^{[1
]}

Guanti, G ^{[1
]}

Riva, R ^{[1
]}

Riu, A ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 32期

关键词：

ugi multicomponent reaction; hydroxamic acids; hydroxylamines; metalloprotease inhibitors;

D O I：

10.1016/j.tetlet.2004.06.068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ugi condensations with O-protected hydroxylamines have been successfully performed in THE using ZnCl2 as activating agent. This synthetic strategy opens up the route to a very convergent assemblage of 'internal' hydroxamic acid derivatives (N-acyl-N-hydroxypeptides). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6109 / 6111

页数：3

共 31 条

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