Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

被引：119

作者：

Godula, Kamil ^{[1
,4
]}

Rabuka, David ^{[1
,4
]}

Nam, Ki Tae ^{[1
,4
]}

Bertozzi, Carolyn R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 27期

关键词：

click chemistry; glycopolymers; micropatterning; mucin; polymerization; CARBOHYDRATE-PROTEIN INTERACTIONS; SURFACE-PLASMON RESONANCE; CLICK CHEMISTRY; QUANTITATIVE-ANALYSIS; RAFT POLYMERIZATION; MULTIVALENT LIGANDS; CARBON NANOTUBES; GLYCAN ARRAY; BINDING; OLIGOSACCHARIDE;

D O I：

10.1002/anie.200805756

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR=fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a copper catalyst. The surface-bound glycopolymers bind lectins in a ligand-specific manner. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4973 / 4976

页数：4

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