Biomimetic engineering of carbon nanotubes by using cell surface mucin mimics

被引：112

作者：

Chen, X

Lee, GS

Zettl, A ^{[1
]}

Bertozzi, CR

机构：

[1] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 45期

关键词：

biomimetic synthesis; bioorganic chemistry; glycoproteins; nanotubes;

D O I：

10.1002/anie.200460620

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible nanotubes: Clycosylated polymers designed to mimic natural mucins were assembled on carbon nanotubes (see picture). Carbon nanotubes coated with mucin mimics were soluble in water, resisted nonspecific protein binding, and bound specifically to biomolecules through receptor-ligand interactions.

引用

收藏

页码：6111 / 6116

页数：6

相关论文

共 19 条

[1] The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[2] Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].

Chen, RJ ;

Bangsaruntip, S ;

Drouvalakis, KA ;

Kam, NWS ;

Shim, M ;

Li, YM ;

Kim, W ;

Utz, PJ ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989

[3] EFFECTS OF GLYCOSYLATION ON THE CONFORMATION AND DYNAMICS OF O-LINKED GLYCOPROTEINS - C-13 NMR-STUDIES OF OVINE SUBMAXILLARY MUCIN [J].

GERKEN, TA ;

BUTENHOF, KJ ;

SHOGREN, R .

BIOCHEMISTRY, 1989, 28 (13) :5536-5543

[4]

HIKENS J, 1992, TRENDS BIOCHEM SCI, V17, P359

[5] Biomimetic engineering of non-adhesive glycocalyx-like surfaces using oligosaccharide surfactant polymers [J].

Holland, NB ;

Qiu, YX ;

Ruegsegger, M ;

Marchant, RE .

NATURE, 1998, 392 (6678) :799-801

[6]

LEE GS, UNPUB J AM CHEM SOC

[7] Advances toward bioapplications of carbon nanotubes [J].

Lin, Y ;

Taylor, S ;

Li, HP ;

Fernando, KAS ;

Qu, LW ;

Wang, W ;

Gu, LR ;

Zhou, B ;

Sun, YP .

JOURNAL OF MATERIALS CHEMISTRY, 2004, 14 (04) :527-541

[8] Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins [J].

Live, DH ;

Williams, LJ ;

Kuduk, SD ;

Schwarz, JB ;

Glunz, PW ;

Chen, XT ;

Sames, D ;

Kumar, RA ;

Danishefsky, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3489-3493

[9] Synthesis of oxime-linked mucin mimics containing the tumor-related TN and sialyl TN antigens [J].

Marcaurelle, LA ;

Shin, YS ;

Goon, S ;

Bertozzi, CR .

ORGANIC LETTERS, 2001, 3 (23) :3691-3694

[10] Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth [J].

Mattson, MP ;

Haddon, RC ;

Rao, AM .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2000, 14 (03) :175-182