Lipase-Catalyzed Ring-Opening Polymerization of the O-Carboxylic Anhydride Derived from Lactic Acid

被引:42
作者
Bonduelle, Colin
Martin-Vaca, Blanca
Bourissou, Didier [1 ]
机构
[1] Univ Toulouse, UPS, LHFA, F-31062 Toulouse, France
关键词
SYNTHETIC BIODEGRADABLE POLYMERS; ORGANIC MEDIA; ENZYMATIC POLYMERIZATION; CHEMOENZYMATIC SYNTHESIS; CYCLIC ESTERS; POLYESTERS; COPOLYMERIZATION; LACTONES; POLYLACTIDE;
D O I
10.1021/bm9007343
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Both lipase PS and Novozym 435 promote the ring-opening polymerization of lacOCA, the O-carboxylic anhydride derived from lactic acid. Accordingly, PLA of relatively high molecular weights (M-n up to 38400 g/mol) and low polydispersities (M-w/M-n < 1.4) are obtained in high yields within a few hours at 80 degrees C. Slight preference for L-lacOCA over D-lacOCA is observed, and with Novozym 435, the molecular weight of the obtained PLA can be controlled by varying the lipase loading.
引用
收藏
页码:3069 / 3073
页数:5
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