ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

被引：1235

作者：

de Castro, Edouard

Sigrist, Christian J. A.

Gattiker, Alexandre

Bulliard, Virginie

Langendijk-Genevaux, Petra S.

Gasteiger, Elisabeth

Bairoch, Amos

Hulo, Nicolas

机构：

[1] Swiss Inst Bioinformat, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Struct Biol & Bioinformat Dept, CH-1211 Geneva 4, Switzerland

[3] Natl Inst Technol & Evaluat, Shibuya Ku, Tokyo 1510066, Japan

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkl124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ScanProsite-http://www.expasy.org/tools/scanprosite/-is a new and improved version of the web-based tool for detecting PROSITE signature matches in protein sequences. For a number of PROSITE profiles, the tool now makes use of ProRules-context-dependent annotation templates-to detect functional and structural intra-domain residues. The detection of those features enhances the power of function prediction based on profiles. Both user-defined sequences and sequences from the UniProt Knowledgebase can be matched against custom patterns, or against PROSITE signatures. To improve response times, matches of sequences from UniProtKB against PROSITE signatures are now retrieved from a pre-computed match database. Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results.

引用

页码：W362 / W365

页数：4

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