A structural view of microtubule dynamics

被引：77

作者：

Nogales, E ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 1-2期

关键词：

tubulin; microtubule; dynamic instability; nucleotide; structure; electron crystallography;

D O I：

10.1007/s000180050012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The essential microtubule property of dynamic instability is based on the binding, hydrolysis and exchange of GTP in each tubulin dimer. The recent high-resolution structures of tubulin and the microtubule have given us the first view at atomic level of properties such as nucleotide exchangeability, the linkage between polymerization and nucleotide hydrolysis, and the origin of microtubule destabilization, as well as the mode of action of antimitotic agents such as taxol.

引用

页码：133 / 142

页数：10

共 41 条

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