Molecular complexity of vertebrate tight junctions (Review)

被引：91

作者：

D'Atri, F

Citi, S

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

[3] Univ Padua, Dept Biol, Padua, Italy

来源：

MOLECULAR MEMBRANE BIOLOGY | 2002年 / 19卷 / 02期

关键词：

epithelia; endothelia; polarity; tight junction; protein;

D O I：

10.1080/09687680210129236

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Separation of distinct body, organ and tissue compartments, and maintenance of epithelial cell polarity require tight junctions (TJ)-cell-cell junctions located in the apicolateral regions of epithelial and endothelial cells. Studies on the protein components of vertebrate TJ have revealed an intricate network of membrane, sub-membrane, cytoskeletal, and signalling molecules. How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology.

引用

页码：103 / 112

页数：10

共 113 条

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