A Microfluidic High-Resolution NMR Flow Probe

被引：119

作者：

Bart, Jacob ^{[2
]}

Kolkman, Ard J. ^{[1
]}

Oosthoek-de Vries, Anna Jo ^{[1
]}

Koch, Kaspar ^{[1
]}

Nieuwland, Pieter J. ^{[1
]}

Janssen, Hans ^{[1
]}

van Bentum, P. J. M. ^{[1
]}

Ampt, Kirsten A. M. ^{[1
]}

Rutjes, Floris P. J. T. ^{[1
]}

Wijmenga, Sybren S. ^{[1
]}

Gardeniers, Han ^{[2
]}

Kentgens, Arno P. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, Dept Phys Chem & Synthet Organ Chem, NL-6525 AJ Nijmegen, Netherlands

[2] Univ Twente, Mesa Inst Nanotechnol, NL-7522 NB Enschede, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 14期

关键词：

MEASURING REACTION-KINETICS; MICROCOIL NMR; SPECTROSCOPY; RESONANCE; SAMPLES;

D O I：

10.1021/ja900389x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.

引用

页码：5014 / +

页数：3

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