共 27 条
The dynamics of estrogen receptor activity
被引:12
作者:
Ciana, P.
Scarlatti, F.
Biserni, A.
Ottobrini, L.
Brena, A.
Lana, A.
Zagari, F.
Lucignani, G.
Maggi, A.
机构:
[1] Univ Milan, Ctr Excellence Neurodegenerat Dis, Dept Pharmacol Sci, I-20133 Milan, Italy
[2] Univ Milan, European Inst Oncol, Inst Radiol Sci, Unit Mol Imaging, Milan, Italy
来源:
关键词:
drug evaluation;
transgenic mice;
pre-clinical animal models;
molecular imaging;
bioluminescence;
luciferase;
estrogen receptors;
intracellular receptors;
insulators;
SERMs;
D O I:
10.1016/j.maturitas.2006.04.016
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
In the latest few years, the merging of imaging and animal engineering technologies has led to the generation of innovative tools that provide the opportunity to look into the dynamics of specific molecular events in living animals during their entire life under a completely renewed perspective. These tools will have a profound impact not only on basic research, but also on drug discovery and development allowing to depict the activity of any therapeutic agents in all their designed targets as well as in the organs where they may cause undesired effects. Along this research line, our laboratory has recently described the first animal model reporting the state of activity of estrogen receptors (ERs) in real time: the ERE-luc reporter mouse. The application of optical imaging to the ERE-luc has allowed an unprecedented in depth view of estrogen signaling in all of its target tissues. For example, the analysis of the state of activity of ERs in the physiological setting of the estrous cycle has provided compelling evidence that hormone-independent mechanisms are responsible for activating ERs in non-reproductive organs. This discovery may pave the way to a rational basis for the development of novel, more selective and effective. treatments for menopause. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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页码:315 / 320
页数:6
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