Pyrrole syntheses based on titanium-catalyzed hydroamination of diynes

被引：140

作者：

Ramanathan, B ^{[1
]}

Keith, AJ ^{[1
]}

Armstrong, D ^{[1
]}

Odom, AL ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 17期

关键词：

D O I：

10.1021/ol0489088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanium-catalyzed hydroamination of 1,4- and 1,5-diynes by primary amines leads to imino-alkynes that undergo in situ 5-endo dig and 5-exo dig cyclization reactions, respectively. The products are 1,2,5-trisubsituted pyrroles accessed directly from readily available diyne starting materials.

引用

页码：2957 / 2960

页数：4

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