Multivalent RGD synthetic peptides as potent αVβ3 integrin ligands

被引：76

作者：

Garanger, E

Boturyn, D

Coll, JL

Favrot, MC

Dumy, P

机构：

[1] Univ Grenoble 1, CNRS, LEDSS, UMR 5616, F-38041 Grenoble 9, France

[2] Inst Albert Bonniot, INSERM, U578, Grp Rech Canc Poumon, F-38706 La Tronche, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 10期

关键词：

D O I：

10.1039/b517706e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We study herein the multivalency effect of a cluster of alpha(v)beta(3)-ligands held on a cyclodecapeptide template. An array of RAFT(c[-RGDfK-])(n) derivatives containing from one to sixteen clustered RGD motifs were synthesized and comparatively assayed in vitro on alpha(v)beta(3)-expressing cells. Efficient inhibition of the alpha(v)beta(3)-specific 23C6 monoclonal antibody fixation was observed with ligands displaying three and four copies of the cyclo[-RGDfK-] peptide.

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页码：1958 / 1965

页数：8

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