Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

被引：268

作者：

Hozumi, K

Negishi, N

Suzuki, D

Abe, N

Sotomaru, Y

Tamaoki, N

Mailhos, C

Ish-Horowicz, D

Habu, S ^{[1
]}

Owen, MJ

机构：

[1] Tokai Univ, Sch Med, Dept Immunol, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Ctr Embryogenesis & Organogenesis, Kanagawa 2591193, Japan

[3] Canc Res UK, Lymphocyte Mol Biol Lab, London WC2A 3PX, England

[4] Cent Inst Expt Anim, Kanagawa 2160001, Japan

[5] Canc Res UK, Dev Genet Lab, London WC2A 3PX, England

[6] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/ni1075

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Notch receptors and their ligands contribute to many developmental systems, but it is not apparent how they function after birth, as their null mutants develop severe defects during embryogenesis. Here we used the Cre-loxP system to delete the Delta-like 1 gene (Dll1) after birth and demonstrated the complete disappearance of splenic marginal zone B cells in Dll1-null mice. In contrast, T cell development was unaffected. These results demonstrated that Dll1 was dispensable as a ligand for Notch1 at the branch point of T cell-B cell development but was essential for the generation of marginal zone B cells. Thus, Notch signaling is essential for lymphocyte development in vivo, but there is a redundancy of Notch-Notch ligand signaling that can drive T cell development within the thymus.

引用

页码：638 / 644

页数：7

共 41 条

[11] Transcription and demethylation of TCR beta gene initiate prior to the gene rearrangement in c-kit(+) thymocytes with CD3 expression: Evidence of T cell commitment in the thymus [J].