Efficient two-phase Suzuki reaction catalyzed by palladium complexes with water-soluble phosphine ligands and detergents as phase transfer reagents

被引：73

作者：

Paetzold, E ^{[1
]}

Oehme, G ^{[1
]}

机构：

[1] Univ Rostock eV, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2000年 / 152卷 / 1-2期

关键词：

carbon-carbon coupling; Suzuki reaction; two-phase system; water-soluble catalyst; detergents;

D O I：

10.1016/S1381-1169(99)00286-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The coupling reaction of iodoanisole and phenylboronic acid occurs in aqueous medium in presence of palladium complexes with water-soluble phosphine ligands with good yields (> 99%). The complex PdCl2[Ph2P(CH2),SO3K](2) is an excellent precursor to catalyze the coupling reactions of aryl halides with arylboronic acid in toluene/ethanol/water with sodium carbonate as base and surfactants as phase transfer reagents between 30 degrees C and 78 degrees C. With increasing concentration of the surfactant the rates of the reactions were increased and the formation of byproducts was suppressed. The catalytic system was active down to the ppm range. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：69 / 76

页数：8

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