Paramagnetic Gd-based gold glyconanoparticles as probes for MRI: tuning relaxivities with sugars

被引：65

作者：

Marradi, Marco ^{[1
,2
]}

Alcantara, David ^{[1
,2
]}

Martinez de la Fuente, Jesus ^{[1
,2
]}

Luisa Garcia-Martin, Maria ^{[1
,2
]}

Cerdan, Sebastian ^{[3
]}

Penades, Soledad ^{[1
,2
]}

机构：

[1] CIC BiomaGUNE CIBER BBN, Lab GlycoNanotechnol, E-20009 San Sebastian, Spain

[2] IIQ CSIC, E-20009 San Sebastian, Spain

[3] CSIC, Inst Invest Biomed Alberto Sols, E-28029 Madrid, Spain

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 26期

关键词：

CONTRAST AGENTS; GADOLINIUM(III) COMPLEXES; NANOPARTICLES; RECEPTOR; CHELATE; TOOLS;

D O I：

10.1039/b900957d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combining sugar conjugates and DO3A-Gd complexes, paramagnetic gold glyconanoparticles (GNPs) with different relaxivity values were obtained and tested in vivo as MRI probes.

引用

页码：3922 / 3924

页数：3

共 33 条

[1] Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI [J].

Accardo, A ;

Tesauro, D ;

Roscigno, P ;

Gianolio, E ;

Paduano, L ;

D'Errico, G ;

Pedone, C ;

Morelli, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) :3097-3107

[2] Gadolinium(III) complexes of dota-derived N-sulfonylacetamides (H4(dota-NHSO2R)=10-{2-[(R)sulfonylamino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid):: A new class of relaxation agents for magnetic resonance imaging applications [J].

Aime, S ;

Botta, M ;

Cravotto, G ;

Frullano, L ;

Giovenzana, GB ;

Crich, SG ;

Palmisano, G ;

Sisti, M .

HELVETICA CHIMICA ACTA, 2005, 88 (03) :588-603

[3]

Aime S, 2001, CHEMISTRY OF CONTRAST AGENTS IN MEDICAL MAGNETIC RESONANCE IMAGING, P193

[4] Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one [J].

Aime, Silvio ;

Castelli, Daniela Delli ;

Lawson, Dale ;

Terreno, Enzo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2430-+

[5] Gold nanoparticles designed for combining dual modality imaging and radiotherapy [J].

Alric, Christophe ;

Serduc, Raphael ;

Mandon, Celine ;

Taleb, Jacqueline ;

Le Duc, Geraldine ;

Le Meur-Herland, Alice ;

Billotey, Claire ;

Perriat, Pascal ;

Roux, Stephane ;

Tillement, Olivier .

GOLD BULLETIN, 2008, 41 (02) :90-97

[6] Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging [J].

Alric, Christophe ;

Taleb, Jacqueline ;

Le Duc, Geraldine ;

Mandon, Celine ;

Billotey, Claire ;

Le Meur-Herland, Alice ;

Brochard, Thierry ;

Vocanson, Francis ;

Janier, Marc ;

Perriat, Pascal ;

Roux, Stephane ;

Tillement, Olivier .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) :5908-5915

[7] GALACTOSE AND N-ACETYLGALACTOSAMINE-SPECIFIC ENDOCYTOSIS OF GLYCOPEPTIDES BY ISOLATED RAT HEPATOCYTES [J].

BAENZIGER, JU ;

FIETE, D .

CELL, 1980, 22 (02) :611-620

[8] Gold glyconanoparticles:: Synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies [J].

Barrientos, AG ;

de la Fuente, JM ;

Rojas, TC ;

Fernández, A ;

Penadés, S .

CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (09) :1909-1921

[9]

Botta M, 2000, EUR J INORG CHEM, P399

[10] Hybrid gadolinium oxide nanoparticles:: Multimodal contrast agents for in vivo imaging [J].

Bridot, Jean-Luc ;

Faure, Anne-Charlotte ;

Laurent, Sophie ;

Riviere, Charlotte ;

Billotey, Claire ;

Hiba, Bassem ;

Janier, Marc ;

Josserand, Veronique ;

Coll, Jean-Luc ;

Vander Elst, Luce ;

Muller, Robert ;

Roux, Stephane ;

Perriat, Pascal ;

Tillement, Olivier .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (16) :5076-5084

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