Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom

被引：1562

作者：

Durand, Neva C. ^{[1
,2
,3
,4
]}

Robinson, James T. ^{[1
,4
]}

Shamim, Muhammad S. ^{[1
,2
,3
]}

Machol, Ido ^{[1
,2
,3
]}

Mesirov, Jill P. ^{[4
]}

Lander, Eric S. ^{[4
,5
,6
]}

Aiden, Erez Lieberman ^{[1
,2
,3
,4
,7
]}

机构：

[1] Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] Rice Univ, Dept Computat & Appl Math, Dept Comp Sci, Houston, TX 77005 USA

[4] Broad Inst Harvard & Massachusetts Inst Technol, Cambridge, MA 02139 USA

[5] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[6] Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA

[7] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77030 USA

来源：

CELL SYSTEMS | 2016年 / 3卷 / 01期

基金：

美国国家科学基金会;

关键词：

HUMAN GENOME; PRINCIPLES;

D O I：

10.1016/j.cels.2015.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hi-C experiments study how genomes fold in 3D, generating contact maps containing features as small as 20 bp and as large as 200 Mb. Here we introduce Juicebox, a tool for exploring Hi-C and other contact map data. Juicebox allows users to zoom in and out of Hi-C maps interactively, just as a user of Google Earth might zoom in and out of a geographic map. Maps can be compared to one another, or to 1D tracks or 2D feature sets.

引用

页码：99 / 101

页数：3

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