In vivo plasmid DNA electrotransfer

被引：48

作者：

Bigey, P ^{[1
]}

Bureau, MF ^{[1
]}

Scherman, D ^{[1
]}

机构：

[1] CRVA Aventis, UMR 7001 CNRS, ENSCP,Lab 3C05, Lab Chim Bioorgan & Biotechnol Mol & Cellulaire, F-94403 Vitry Sur Seine, France

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(02)00377-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In vivo electrotransfer is a physical technique for gene delivery in various mammalian tissues, which involves the injection of plasmid DNA into a target tissue and administration of an electric field. Its ease of performance, as well as recent understanding of its mechanism and applications to different mammalian tissues such as skeletal muscle, liver, brain and tumors, makes it a powerful technique. It could be used in gene therapy and as a laboratory tool to study gene functions.

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页码：443 / 447

页数：5

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