Axonal wiring in the mouse olfactory system

被引:215
作者
Mombaerts, Peter [1 ]
机构
[1] Rockefeller Univ, New York, NY 10021 USA
关键词
olfaction; olfactory receptor; odorant receptor; glomerular array; axon guidance;
D O I
10.1146/annurev.cellbio.21.012804.093915
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The main olfactory epithelium of the mouse is a mosaic of 2000 populations of olfactory sensory neurons (OSNs). Each population expresses one allele of one of the 1000 intact odorant receptor (OR) genes. An OSN projects a single unbranched axon to a single glomerulus, from an array of 1600-1800 glomeruli in the main olfactory bulb. Within a glomerulus the OSN axon synapses with the dendrites of second-order neurons and interneurons. Axons of OSNs that express the same OR project to the same glomeruli-typically one glomerulus per half-bulb and thus four glomeruli per mouse. These glomeruli are located at characteristic positions within the glomerular layer of the bulb. ORs determine both the odorant response profile of the OSN and the projection of its axon to a specific glomerulus. I focus on genetic approaches to the axonal wiring problem, particularly on how ORs may function in axonal wiring.
引用
收藏
页码:713 / 737
页数:25
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