New steroidal alkaloids from the bulbs of Fritillaria puqiensis

被引：46

作者：

Jiang, Yan ^{[1
]}

Li, Ping ^{[1
]}

Li, Hui-Jun ^{[1
]}

Yu, Hua ^{[1
]}

机构：

[1] China Pharmaceut Univ, MOE Key Lab Modern Chinese Med, Dept Pharmacognosy, Nanjing 210009, Peoples R China

来源：

STEROIDS | 2006年 / 71卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Fritillaria puqiensis; steroidal alkaloids; puqienines C-E; puqiedine; 3; alpha-puqiedin-7-ol; puqietinedione;

D O I：

10.1016/j.steroids.2006.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Six new steroidal alkaloids, namely puqienines C-E (1-3), pucliedine (4), 3 alpha-puqiedin-7-ol (5), and puqietinedione (6), along with two known steroidal alkaloids puqiedinone (7) and peimisine (8), were isolated from the bulbs of Fritillaria puqiensis G.D. Yu et G.Y. Chen (Liliaceae). Their structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR experiments. Among these alkaloids, 1-3 had a veratramine-type skeleton, 4,5, 7 a cevanine-type skeleton, 6 a secosolanidine-type skeleton, and 8 a jervine-type skeleton. The existence of multiple types of steroidal skeletons, especially of relatively large amount of veratramine-type alkaloids in one species is rare in the genus Fritillaria, and the results might be of chemotaxonomic significance for this species. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：843 / 848

页数：6

共 22 条

[1]

New class of steroidal alkaloids from Fritillaria imperialis [J].