Decrement of blood flow precedes the involution of the ventral prostate in the rat after castration

被引:92
作者
Lekas, E
Johansson, M
Widmark, A
Bergh, A
Damber, JE
机构
[1] UMEA UNIV,DEPT UROL & ANDROL,S-90187 UMEA,SWEDEN
[2] UMEA UNIV,DEPT PHYSIOL,S-90187 UMEA,SWEDEN
[3] UMEA UNIV,DEPT ONCOL,UMEA,SWEDEN
来源
UROLOGICAL RESEARCH | 1997年 / 25卷 / 05期
关键词
prostate; castration; apoptosis; blood flow; radioactive microspheres; androgen receptors;
D O I
10.1007/BF01294656
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Blood flow to the rat ventral prostate (VP), dorsolateral prostate (DP), and Dunning R3327 prostatic tumors was measured at different times up to 7 days after castration, using the microsphere method. In the VP organ weight was decreased from day 3 onwards. Blood flow was, however, already significantly decreased from day 1. The reduced blood flow in VP in 1-3 and 7-day castrated animals could be reversed by testosterone treatment. Organ weight was slightly decreased but blood flow was unaffected by castration in DP. Castration left Dunning tumor volume and blood flow unaffected. Using immunohistochemistry, androgen receptors were observed in epithelial and stromal cells in VP, DP and Dunning tumors, but not in blood vessels. Castration is known to induce apoptosis in the VP, but not in the DP or in Dunning tumors. This suggests that a reduction in blood flow might be an important component for the castration-induced involution and apoptosis in prostatic tissue. The reason why castration reduces blood flow only in the VP, and not in the DP or Dunning tumor is unknown.
引用
收藏
页码:309 / 314
页数:6
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