Mapping genes for complex traits in domestic animals and their use in breeding programmes

被引:724
作者
Goddard, Michael E. [1 ,2 ]
Hayes, Ben J. [2 ]
机构
[1] Univ Melbourne, Dept Agr & Food Syst, Parkville, Vic 3010, Australia
[2] Dept Primary Ind, Biosci Res Div, Bundoora, Vic 3083, Australia
关键词
EFFECTIVE POPULATION-SIZE; LINKAGE DISEQUILIBRIUM; DAIRY-CATTLE; FOOD CONVERSION; HOLSTEIN CATTLE; MYOSTATIN GENE; GENOME SCAN; DGAT1; GENE; LOCI; MUTATION;
D O I
10.1038/nrg2575
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Genome-wide panels of SNPs have recently been used in domestic animal species to map and identify genes for many traits and to select genetically desirable livestock. This has led to the discovery of the causal genes and mutations for several single-gene traits but not for complex traits. However, the genetic merit of animals can still be estimated by genomic selection, which uses genome-wide SNP panels as markers and statistical methods that capture the effects of large numbers of SNPs simultaneously. This approach is expected to double the rate of genetic improvement per year in many livestock systems.
引用
收藏
页码:381 / 391
页数:11
相关论文
共 70 条
  • [51] Plastow G, 2003, P 28 ANN M NAT SWIN, P151
  • [52] RELATIONSHIPS BETWEEN BLOOD GROUPS AND FAT PERCENTAGE OF MILK IN CATTLE
    RENDEL, J
    [J]. NATURE, 1961, 189 (476) : 408 - &
  • [53] Common variants in the GDF5-UQCC region are associated with variation in human height
    Sanna, Serena
    Jackson, Anne U.
    Nagaraja, Ramaiah
    Willer, Cristen J.
    Chen, Wei-Min
    Bonnycastle, Lori L.
    Shen, Haiqing
    Timpson, Nicholas
    Lettre, Guillaume
    Usala, Gianluca
    Chines, Peter S.
    Stringham, Heather M.
    Scott, Laura J.
    Dei, Mariano
    Lai, Sandra
    Albai, Giuseppe
    Crisponi, Laura
    Naitza, Silvia
    Doheny, Kimberly F.
    Pugh, Elizabeth W.
    Ben-Shlomo, Yoav
    Ebrahim, Shah
    Lawlor, Debbie A.
    Bergman, Richard N.
    Watanabe, Richard M.
    Uda, Manuela
    Tuomilehto, Jaakko
    Coresh, Josef
    Hirschhorn, Joel N.
    Shuldiner, Alan R.
    Schlessinger, David
    Collins, Francis S.
    Smith, George Davey
    Boerwinkle, Eric
    Cao, Antonio
    Boehnke, Michael
    Abecasis, Goncalo R.
    Mohlke, Karen L.
    [J]. NATURE GENETICS, 2008, 40 (02) : 198 - 203
  • [54] Strategy for applying genome-wide selection in dairy cattle
    Schaeffer, L. R.
    [J]. JOURNAL OF ANIMAL BREEDING AND GENETICS, 2006, 123 (04) : 218 - 223
  • [55] IDENTIFICATION AND PREVALENCE OF A GENETIC-DEFECT THAT CAUSES LEUKOCYTE ADHESION DEFICIENCY IN HOLSTEIN CATTLE
    SHUSTER, DE
    KEHRLI, ME
    ACKERMANN, MR
    GILBERT, RO
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 9225 - 9229
  • [56] IMPROVEMENT OF METRIC TRAITS THROUGH SPECIFIC GENETIC LOCI
    SMITH, C
    [J]. ANIMAL PRODUCTION, 1967, 9 : 349 - &
  • [57] Characterization of the DGAT1 gene in the New Zealand dairy population
    Spelman, RJ
    Ford, CA
    McElhinney, P
    Gregory, GC
    Snell, RG
    [J]. JOURNAL OF DAIRY SCIENCE, 2002, 85 (12) : 3514 - 3517
  • [58] Extensive and breed-specific linkage disequilibrium in Canis familiaris
    Sutter, NB
    Eberle, MA
    Parker, HG
    Pullar, BJ
    Kirkness, EF
    Kruglyak, L
    Ostrander, EA
    [J]. GENOME RESEARCH, 2004, 14 (12) : 2388 - 2396
  • [59] SVED J A, 1971, Theoretical Population Biology, V2, P125
  • [60] TANTIA MS, 2006, BMC VET RES, V7, P32