Cdk5: mediator of neuronal death and survival

被引：74

作者：

Cheung, ZH ^{[1
]}

Ip, NY ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2004年 / 361卷 / 1-3期

关键词：

p35; p39; apoptosis; Alzheimer's disease; neuronal survival; ErbB receptor; NMDA receptor;

D O I：

10.1016/j.neulet.2003.12.117

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests. Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Here we summarize the recent findings on Cdk5 not only as an important participant in neuronal death, but also a key player in neuronal survival. Elucidating the mechanisms of regulation of Cdk5 and its downstream signaling might prove to be crucial in the therapeutic treatment of neurodegenerative diseases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 51

页数：5

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