The catalytic ortho-arylation of tyrosine

被引：42

作者：

Bedford, Robin B. ^{[1
]}

Haddow, Mairi F. ^{[1
]}

Webster, Ruth L. ^{[1
]}

Mitchell, Charlotte J. ^{[2
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

STREPTOMYCES SP TU-6075; SACC; TC; 1093; PROTEASOME INHIBITORS; BIOLOGICAL-ACTIVITIES; ARYLOMYCIN-A; PHENOLS; DERIVATIVES; COUPLINGS; TAXONOMY; RP-66453;

D O I：

10.1039/b906119c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

引用

页码：3119 / 3127

页数：9

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