Pathological-Condition-Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection

被引：174

作者：

Li, Li-Li ^{[1
]}

Ma, Huai-Lei ^{[1
]}

Qi, Guo-Bin ^{[2
]}

Zhang, Di ^{[1
]}

Yu, Faquan ^{[2
]}

Hu, Zhiyuan ^{[1
,3
]}

Wang, Hao ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol NCNST, Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, Wuhan 430073, Peoples R China

[3] Yangtze River Delta Acad Nanotechnol & Ind Dev Re, Jiaxing 314000, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 02期

基金：

中国国家自然科学基金; 中国博士后科学基金; 北京市自然科学基金;

关键词：

FUNCTIONAL PHOTOACOUSTIC MICROSCOPY; IN-VIVO; CARBON NANOTUBES; LIVING MICE; CONTRAST AGENTS; IMAGING PROBES; NANOPARTICLES; CANCER; SYSTEM; CELLS;

D O I：

10.1002/adma.201503437

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pyropheophorbide-α-based building block (Ppa-PLGVRG-Van) can be used to construct self-aggregated superstructures in vivo for highly specific and sensitive diagnosis of bacterial infection by noninvasive photoacoustic tomography. This in vivo supramolecular chemistry approach opens a new avenue for efficient, rapid, and early-stage disease diagnosis with high sensitivity and specificity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：254 / 262

页数：9

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