Self-assembly of block copolymers derived from elastin-mimetic polypeptide sequences

被引：241

作者：

Wright, ER ^{[1
]}

Conticello, VP ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 08期

关键词：

elastin; biomaterials; protein polymer; nanoparticle; hydrogel; genetic engineering;

D O I：

10.1016/S0169-409X(02)00059-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Protein polymers derived from elastin-mimetic peptide sequences can be synthesized with near-absolute control of macromolecular architecture using genetic engineering techniques. Elastin-mimetic diblock and triblock copolymers have been prepared using this approach in which the individual elastin blocks display different phase behavior in aqueous solution. The selective collapse of the more hydrophobic blocks above the lower critical solution temperature was employed to drive the thermo-reversible self-assembly of elastin-mimetic diblock and triblock copolymer into protein-based nanoparticles and nano-textured hydrogels, respectively. These materials display considerable promise as biomaterials for applications in drug delivery and soft tissue augmentation. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1057 / 1073

页数：17

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[21]

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[22] Morphology and rheology of SIS and SEPS triblock copolymers in the presence of a midblock-selective solvent [J].