Bioactive Constituents of the Stem Bark of Beilschmiedia zenkeri

被引：40

作者：

Lenta, Bruno Ndjakou ^{[1
,2
]}

Tantangmo, Ferdinand ^{[3
]}

Devkota, Krishna Prasad ^{[2
]}

Wansi, Jean Duplex ^{[2
]}

Chouna, Jean Rodolphe ^{[3
]}

Soh, Rene Cosme Fongang ^{[3
]}

Neumann, Beate ^{[2
]}

Stammler, Hans-Georg ^{[2
]}

Tsamo, Etienne ^{[3
]}

Sewald, Norbert ^{[2
]}

机构：

[1] Univ Yaounde I, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon

[2] Univ Bielefeld, Dept Chem, D-33501 Bielefeld, Germany

[3] Univ Yaounde I, Dept Organ Chem, Yaounde, Cameroon

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 12期

关键词：

ENDIANDRIC ACID; FLAVONOIDS; BENZOPYRAN; GLYCOSIDES; LIGNANS; SPECTRA; EXTRACT; AMIDES;

D O I：

10.1021/np900341f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the stem bark of Beilschmiedia zenkeri led to the isolation of four new methoxylated flavonoid derivatives, (2S,4R)-5,6,7-trimethoxyflavan-4-ol (1), (2S,4R)-4,5,6,7-tetramethoxyflavan (2), beilschmieflavonoid A (3), and beilschmieflavonoid B (4), together with seven known compounds. The structures of 1-4 were established by spectroscopic methods, and their relative configurations confirmed by X-ray crystallographic and CD analysis. The isolated compounds were evaluated in vitro for their antibacterial activity against three strains of bacteria, Pseudomonas agarici, Bacillus subtilis, and Streptococcus minor, and for their antiplasmodial activity against Plasmodium falciparum, chloroquine-resistant strain W2.

引用

页码：2130 / 2134

页数：5

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