Nutrigenomics: exploiting systems biology in the nutrition and health arena

被引:125
作者
van Ommen, B [1 ]
Stierum, R [1 ]
机构
[1] TNO Nutr & Food Res, NL-3700 AJ Zeist, Netherlands
关键词
D O I
10.1016/S0958-1669(02)00349-X
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Nutritional sciences are discovering the application of the so-called 'omics' sciences. Propelled by the recent unravelling of the human genome and the coinciding technological developments, genotyping, transcriptomics, proteomics and metabolomics are now available to nutritional research. In the future we are likely to see new screening tools for the selection of bioactive nutrients, new biomarkers for the in vivo efficacy of nutrients, and better insight into the influence of genetic polymorphisms on nutrient metabolism. However, are these promises just based on biotechnological hype or is a real fundamental change in human nutritional sciences at hand?.
引用
收藏
页码:517 / 521
页数:5
相关论文
共 28 条
[11]  
Mariadason JM, 2000, CANCER RES, V60, P4561
[12]   Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency [J].
Petrault, I ;
Zimowska, W ;
Mathieu, J ;
Bayle, D ;
Rock, E ;
Favier, A ;
Rayssiguier, Y ;
Mazur, A .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1586 (01) :92-98
[13]   Gene expression profiling of low selenium status in the mouse intestine: Transcriptional activation of genes linked to DNA damage, cell cycle control and oxidative stress [J].
Rao, L ;
Puschner, B ;
Prolla, TA .
JOURNAL OF NUTRITION, 2001, 131 (12) :3175-3181
[14]   Coronary heart disease in patients with low LDL-cholesterol - Benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors [J].
Sacks, FM ;
Tonkin, AM ;
Craven, T ;
Pfeffer, MA ;
Shepherd, J ;
Keech, A ;
Furberg, CD ;
Braunwald, E .
CIRCULATION, 2002, 105 (12) :1424-1428
[15]  
Seedorf U, 2001, NUTR METAB CARDIOVAS, V11, P189
[16]  
Soukas A, 2000, GENE DEV, V14, P963
[17]   Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle [J].
Sreekumar, R ;
Unnikrishnan, J ;
Fu, A ;
Nygren, J ;
Short, KR ;
Schimke, J ;
Barazzoni, R ;
Nair, KS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (01) :E38-E43
[18]   Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle [J].
Sreekumar, R ;
Unnikrishnan, J ;
Fu, A ;
Nygren, J ;
Short, KR ;
Schimke, J ;
Barazzoni, R ;
Nair, KS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 282 (05) :E1055-E1061
[19]   Regulation of lipid and lipoprotein metabolism by retinoids [J].
Staels, B .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (05) :S158-S167
[20]  
Stierum R, 2001, Nutr Metab Cardiovasc Dis, V11, P94