Quorum sensing and social networking in the microbial world

被引:302
作者
Atkinson, Steve [1 ]
Williams, Paul [1 ]
机构
[1] Univ Nottingham, Sch Mol Med Sci, Ctr Biomol Sci, Nottingham NG7 2RD, England
关键词
quorum sensing; cell-cell communication; interspecies communication; inter-kingdom communication; TO-CELL COMMUNICATION; ACYLATED HOMOSERINE LACTONES; DIFFUSIBLE FRUITING FACTOR; GYP DOMAIN PROTEIN; PSEUDOMONAS-AERUGINOSA; GENE-EXPRESSION; IN-VITRO; XANTHOMONAS-CAMPESTRIS; BIOFILM FORMATION; CANDIDA-ALBICANS;
D O I
10.1098/rsif.2009.0203
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
For many years, bacterial cells were considered primarily as selfish individuals, but, in recent years, it has become evident that, far from operating in isolation, they coordinate collective behaviour in response to environmental challenges using sophisticated intercellular communication networks. Cell-to-cell communication between bacteria is mediated by small diffusible signal molecules that trigger changes in gene expression in response to fluctuations in population density. This process, generally referred to as quorum sensing (QS), controls diverse phenotypes in numerous Gram-positive and Gram-negative bacteria. Recent advances have revealed that bacteria are not limited to communication within their own species but are capable of 'listening in' and 'broadcasting to' unrelated species to intercept messages and coerce cohabitants into behavioural modifications, either for the good of the population or for the benefit of one species over another. It is also evident that QS is not limited to the bacterial kingdom. The study of two-way intercellular signalling networks between bacteria and both uni- and multicellular eukaryotes as well as between eukaryotes is just beginning to unveil a rich diversity of communication pathways.
引用
收藏
页码:959 / 978
页数:20
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