Synthesis of (-)-(4R,5R)-muricatacin using a regio- and stereospecific ring-opening of a vinyl epoxide

被引：45

作者：

Baylon, C

Prestat, G

Heck, MP

Mioskowski, C

机构：

[1] CEA CE Saclay, Dept Mol & Cellular Biol, Serv Mol Marquees, F-91191 Gif Sur Yvette, France

[2] Univ Louis Pasteur Strasbourg 1, Fac Pharm, Associe CNRS, Lab Synthese Bioorgan, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

acetogenin; muricatacin; epoxide; ring-opening;

D O I：

10.1016/S0040-4039(00)00497-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of (-)-muricatacin, a natural acetogenin, has been achieved using as a key step a regio- and stereospecific ring-opening of a substituted vinyl epoxide under Lewis acid catalysis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3833 / 3835

页数：3

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