Long-term survivors in Nairobi: Complete HIV-1 RNA sequences and immunogenetic associations

被引：23

作者：

Fang, GW

Kuiken, C

Weiser, B

Rowland-Jones, S

Plummer, F

Chen, CH

Kaul, R

Anzala, AO

Bwayo, J

Kimani, J

Philpott, SM

Kitchen, C

Sinsheimer, JS

Gaschen, B

Lang, D

Shi, BS

Kemal, KS

Rostron, T

Brunner, C

Beddows, S

Sattenau, Q

Paxinos, E

Oyugi, J

Burger, H

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA

[2] Albany Med Coll, Dept Med, Albany, NY 12208 USA

[3] Los Alamos Natl Lab, Los Alamos, NM USA

[4] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90024 USA

[6] Virologic, San Francisco, CA USA

[7] Univ Oxford, Inst Mol Med, Oxford, England

[8] Univ London Imperial Coll Sci Technol & Med, London, England

[9] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[10] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 04期

关键词：

D O I：

10.1086/421504

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P = .0048). Studying the interaction among immunogenetics, responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.

引用

页码：697 / 701

页数：5

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