Caspase-2: controversial killer or checkpoint controller?

被引：37

作者：

Kitevska, Tanja ^{[1
]}

Spencer, Damian M. S. ^{[1
]}

Hawkins, Christine J. ^{[1
,2
]}

机构：

[1] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia

[2] Royal Childrens Hosp, Childrens Canc Ctr, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

来源：

APOPTOSIS | 2009年 / 14卷 / 07期

基金：

英国医学研究理事会;

关键词：

Caspase; Protease; Apoptosis; Splicing; PIDDosome; Activation; ENDOPLASMIC-RETICULUM STRESS; PROGRAMMED CELL-DEATH; CYTOCHROME-C RELEASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTERACTING PROTEIN RIP; INDUCED APOPTOSIS; DNA-DAMAGE; IN-VITRO; HUNTINGTONS-DISEASE; NUCLEAR-BODIES;

D O I：

10.1007/s10495-009-0365-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The caspases are an evolutionarily conserved family of cysteine proteases, with essential roles in apoptosis or inflammation. Caspase-2 was the second caspase to be cloned and it resembles the prototypical nematode caspase CED-3 more closely than any other mammalian protein. An absence of caspase-2-specific reagents and the subtle phenotype of caspase-2-deficient mice have hampered definition of the physiological role of caspase-2 and identification of factors regulating its activity. Although some data implicate caspase-2 in apoptotic pathways, a link with apoptosis has been less firmly established for caspase-2 than for some other caspases. Emerging evidence suggests that caspase-2 regulates the cell cycle and may act as a tumour suppressor. This article critically reviews the current state of knowledge regarding the biochemistry and biology of this controversial caspase.

引用

页码：829 / 848

页数：20

共 183 条

[21] Engineering a dimeric caspase-9: A re-evaluation of the induced proximity model for caspase activation [J].

Chao, Y ;

Shiozaki, EN ;

Srinivasula, SM ;

Rigotti, DJ ;

Fairman, R ;

Shi, YG .

PLOS BIOLOGY, 2005, 3 (06) :1079-1087

[22] Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: A role for the IAPs [J].

Cheung, Herman H. ;

Kelly, N. Lynn ;

Liston, Peter ;

Korneluk, Robert G. .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (12) :2347-2357

[23] Role of CED-4 in the activation of CED-3 [J].

Chinnaiyan, AM ;

Chaudhary, D ;

ORourke, K ;

Koonin, EV ;

Dixit, VM .

NATURE, 1997, 388 (6644) :728-729

[24] Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor - A novel function for a caspase prodomain [J].

Colussi, PA ;

Harvey, NL ;

Kumar, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24535-24542

[25] Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain [J].

Colussi, PA ;

Harvey, NL ;

Shearwin-Whyatt, LM ;

Kumar, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26566-26570

[26] Caspase cleavage enhances the apoptosis-inducing effects of BAD [J].

Condorelli, F ;

Salomoni, P ;

Cotteret, S ;

Cesi, V ;

Srinivasula, SM ;

Alnemri, ES ;

Calabretta, B .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (09) :3025-3036

[27] The Bcl-2 family: roles in cell survival and oncogenesis [J].

Cory, S ;

Huang, DCS ;

Adams, JM .

ONCOGENE, 2003, 22 (53) :8590-8607

[28] Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion [J].

Côté, J ;

Dupuis, S ;

Wu, JY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :8535-8543

[29] Caspase-2 pre-mRNA alternative splicing:: Identification of an intronic element containing a decoy 3′ acceptor site [J].

Côté, J ;

Dupuis, S ;

Jiang, ZH ;

Wu, JY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :938-943

[30] p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress [J].

Cuenin, S. ;

Tinel, A. ;

Janssens, S. ;

Tschopp, J. .

ONCOGENE, 2008, 27 (03) :387-396

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