Getting to First Base in Proteasome Assembly

被引：61

作者：

Besche, Henrike C. ^{[1
]}

Peth, Andreas ^{[1
]}

Goldberg, Alfred L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CELL | 2009年 / 138卷 / 01期

关键词：

19S REGULATORY PARTICLE; 20S PROTEASOMES; PATHWAY; ATPASES; TERMINI; PROTEIN; GATE;

D O I：

10.1016/j.cell.2009.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assembly of complex structures such as the eukaryotic 26S proteasome requires intricate mechanisms that ensure precise subunit arrangements. Recent studies have shed light on the pathway for ordered assembly of the base of the 19S regulatory particle of the 26S proteasome by identifying new precursor complexes and four dedicated chaperones involved in its assembly.

引用

页码：25 / 28

页数：4

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