Cellular mechanisms and physiological consequences of redox-dependent signalling

被引：1608

作者：

Holmstroem, Kira M. ^{[1
]}

Finkel, Toren ^{[1
]}

机构：

[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-TYROSINE PHOSPHATASES; HYDROGEN-PEROXIDE; LIFE-SPAN; REVERSIBLE INACTIVATION; OXIDATIVE STRESS; PYRUVATE-KINASE; SELF-RENEWAL; DNA-DAMAGE; STEM-CELLS; ROS LEVELS;

D O I：

10.1038/nrm3801

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS), which were originally characterized in terms of their harmful effects on cells and invading microorganisms, are increasingly implicated in various cell fate decisions and signal transduction pathways. The mechanism involved in ROS-dependent signalling involves the reversible oxidation and reduction of specific amino acids, with crucial reactive Cys residues being the most frequent target. In this Review, we discuss the sources of ROS within cells and what is known regarding how intracellular oxidant levels are regulated. We further discuss the recent observations that reduction-oxidation (redox)-dependent regulation has a crucial role in an ever-widening range of biological activities-from immune function to stem cell self-renewal, and from tumorigenesis to ageing.

引用

收藏

页码：411 / 421

页数：11

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