Kinetics of lipase-mediated synthesis of butyl butyrate in n-hexane

被引：21

作者：

Paiva, AL ^{[1
]}

van Rossum, D ^{[1
]}

Malcata, FX ^{[1
]}

机构：

[1] Univ Catolica Portuguesa, Escola Super Biotecnol, P-4200072 Porto, Portugal

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2002年 / 20卷 / 01期

关键词：

alcoholysis; enzyme; Ping Pong BiBi; modeling;

D O I：

10.1080/10242420210151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports experimental and modeling work concerning alcoholysis reactions between butanol and ethyl butanoate, catalyzed by Lipozyme(TM) in n-hexane, using a batch stirred system at 60degreesC. Description of the reaction kinetics was based on a postulated multisubstrate Ping Pong Bi Bi mechanism, and appropriate rate expressions were derived for all components in the reaction medium. Simplified models were fitted by non-linear multiresponse regression analysis to data (experimental or calculated from mass balances, as appropriate) encompassing the concentrations of free butanol, ethyl butanoate, ethanol and butyl butanoate. Finally, incremental F-tests were performed to assess the simplest model form that was able to provide a statistically good fit throughout the entire reaction time frame.

引用

页码：43 / 51

页数：9

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