Preparation of a fluorous chiral BINOL derivative and application to an asymmetric protonation reaction

被引：56

作者：

Nakamura, Y

Takeuchi, S

Ohgo, Y

Curran, DP

机构：

[1] Niigata Coll Pharm, Niigata 9502081, Japan

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 03期

关键词：

fluorous chiral; enantioselective protonation; samarium enolate;

D O I：

10.1016/S0040-4020(99)01004-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorous Chiral Proton Source (R,S)-FDHPEB resulted in a higher enantioselectivity (95% ee) than that of the original nonfluorous (R,S)-DHPEB (87% ee) in an enantioselective protonation of a samarium enolate. (R,S)-FDHPEB was easily recovered by a simple filtration through a fluorous reverse phase silica gel and was recyclable. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：351 / 356

页数：6

共 63 条

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