Micronutrient malnutrition, infection, and immunity: An overview

被引:227
作者
Bhaskaram, P [1 ]
机构
[1] Natl Inst Nutr, Indian Council Med Res, Hyderabad 500007, Andhra Pradesh, India
关键词
D O I
10.1301/00296640260130722
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Micronutrient deficiencies and infectious diseases often coexist and exhibit complex interactions leading to the vicious cycle of malnutrition and infections among underprivileged populations of the developing countries, particularly in preschool children. Several micronutrients such as vitamin A, beta-carotene, folic acid, vitamin Bye, vitamin C, riboflavin, iron, zinc, and selenium, have immunomodulating functions and thus influence the susceptibility of a host to infectious diseases and the course and outcome of such diseases. Certain of these micronutrients also possess antioxidant functions that not only regulate immune homeostasis of the host, but also alter the genome of the microbes, particularly in viruses, resulting in grave consequences like resurgence of old infectious diseases or the emergence of new infections. These micronutrient infection and immune function interactions and their clinical and public health relevance in developing countries are briefly reviewed in this article. (C) 2002 International Life Sciences Institute.
引用
收藏
页码:S40 / S45
页数:6
相关论文
共 52 条
  • [11] EFFECT OF IRON AND VITAMIN-A DEFICIENCIES ON MACROPHAGE FUNCTION IN CHILDREN
    BHASKARAM, P
    SHARADA, K
    SIVAKUMAR, B
    RAO, KV
    NAIR, M
    [J]. NUTRITION RESEARCH, 1989, 9 (01) : 35 - 45
  • [12] BHASKARAM P, 1977, LANCET, V1, P1000
  • [13] Enhancement in seroconversion to measles vaccine with simultaneous administration of vitamin A in 9-months-old Indian infants
    Bhaskaram P.
    Rao K.V.
    [J]. The Indian Journal of Pediatrics, 1997, 64 (4) : 503 - 509
  • [14] BHASKARAM P, 1988, CONT ISSUES CLIN NUT, V11, P149
  • [15] BHASKARAM P, 1998, INDIAN PAEDIAT, V35, P2317
  • [16] SINGLE NUTRIENT DEFICIENCY AND CELL-MEDIATED IMMUNE-RESPONSES .1. ZINC
    CHANDRA, RK
    AU, B
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1980, 33 (04) : 736 - 738
  • [17] CHANDRA RK, 1985, J AM COLL NUTR, V4, P5
  • [19] CHANDRA RK, 1984, CRITICAL REV TROPICA, V2, P93
  • [20] Night blindness of pregnancy in rural Nepal - nutritional and health risks
    Christian, P
    West, KP
    Khatry, SK
    Katz, J
    Shrestha, SR
    Pradhan, EK
    LeClerq, SC
    Pokhrel, RP
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1998, 27 (02) : 231 - 237