Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

被引：27

作者：

Bayer, L

Colard, C

Nguyen, NU

Risold, PY

Fellmann, D

Griffond, B

机构：

[1] Fac Med, Histol Lab, CNRS, ESA 6025, F-25030 Besancon, France

[2] Fac Med, Physiol Lab, CNRS, ESA 6025, F-25030 Besancon, France

来源：

NEUROREPORT | 2000年 / 11卷 / 03期

关键词：

2-deoxyglucose; hypocretin/orexin; lateral hypothalamus; melanin-concentrating hormone; mRNA expression; rat;

D O I：

10.1097/00001756-200002280-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following an i.p. injection of 2-deoxyglucose (2DG), a nonmetabolizable analogue of glucose known to induce intracellular glucopenia, a progressive decrease in the level of hypocretin (Hcrt)/orexin mRNA was observed in the rat lateral hypothalamus while the melanin-concentrating hormone (MCH) expression in neighbouring neurons remained unaffected. This result together with the previously reported stimulation of Hcrt expression by insulin confirms that Hcrt neurons, but not MCH neurons, are sensitive to glucose availability and suggests that they respond through different mechanisms and/or different pathways to intracellular glucopenia and hypoglycemic conditions. NeuroReport 11:531-533 (C) 2000 Lippincott Williams & Wilkins.

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收藏

页码：531 / 533

页数：3

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