Ubiquitin hubs in oncogenic networks

被引：13

作者：

Crosetto, Nicola ^{[1
]}

Bienko, Marzena ^{[1
]}

Dikic, Ivan ^{[1
]}

机构：

[1] Goethe Univ Hosp, Inst Biochem 2, D-60599 Frankfurt, Germany

来源：

MOLECULAR CANCER RESEARCH | 2006年 / 4卷 / 12期

关键词：

D O I：

10.1158/1541-7786.MCR-06-0328

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy.

引用

页码：899 / 904

页数：6

共 36 条

[1] Signal transduction by the TGF-β superfamily
Attisano, L
Wrana, JL
[J]. SCIENCE, 2002, 296 (5573) : 1646 - 1647
[2] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
Bienko, M
Green, CM
Crosetto, N
Rudolf, F
Zapart, G
Coull, B
Kannouche, P
Wider, G
Peter, M
Lehmann, AR
Hofmann, K
Dikic, I
[J]. SCIENCE, 2005, 310 (5755) : 1821 - 1824
[3] Ubiquitin signalling in the NF-κB pathway
Chen, ZJJ
[J]. NATURE CELL BIOLOGY, 2005, 7 (08) : 758 - U19
[4] When ubiquitin meets ubiquitin receptors: a signalling connection
Di Fiore, PP
Polo, S
Hofmann, K
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (06) : 491 - 497
[5] Germ-layer specification and control of cell growth by ectodermin, a Smad4 ubiquitin ligase
Dupont, S
Zacchigna, L
Cordenonsi, M
Soligo, S
Adorno, M
Rugge, M
Piccolo, S
[J]. CELL, 2005, 121 (01) : 87 - 99
[6] Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma
Farinha, P
Gascoyne, RD
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (26) : 6370 - 6378
[7] Oncogenic aberrations of cullin-dependent ubiquitin ligases
Guardavaccaro, D
Pagano, M
[J]. ONCOGENE, 2004, 23 (11) : 2037 - 2049
[8] Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage
Guo, Caixia
Tang, Tie-Shan
Bienko, Marzena
Parker, Joanne L.
Bielen, Aleksandra B.
Sonoda, Eiichiro
Takeda, Shunichi
Ulrich, Helle D.
Dikic, Ivan
Friedberg, Errol C.
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (23) : 8892 - 8900
[9] Ubiquitylation and cell signaling
Haglund, K
Dikic, I
[J]. EMBO JOURNAL, 2005, 24 (19) : 3353 - 3359
[10] The hallmarks of cancer
Hanahan, D
Weinberg, RA
[J]. CELL, 2000, 100 (01) : 57 - 70

← 1 2 3 4 →