Synthesis of γ-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

被引：42

作者：

Casey, Brian M. ^{[1
]}

Eakin, Cynthia A. ^{[1
]}

Flowers, Robert A., II ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 12期

基金：

美国国家卫生研究院;

关键词：

CAN; Cyclobutanol; gamma-Substituted ketone; Oxidative coupling; CERIUM(IV) AMMONIUM-NITRATE; SOLVENT-DEPENDENT CHEMOSELECTIVITIES; RADICAL-CATION; ALKYL-HALIDES; EFFICIENT;

D O I：

10.1016/j.tetlet.2008.12.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1264 / 1266

页数：3

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