Recent developments in NAD(P)H regeneration for enzymatic reductions in one- and two-phase systems

被引：44

作者：

Eckstein, M

Daussmann, T

Kragl, U

机构：

[1] Univ Rostock, Dept Chem, D-18059 Rostock, Germany

[2] JFC Julich Fine Chem GmbH, D-52428 Julich, Germany

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2004年 / 22卷 / 02期

关键词：

alcohol dehydrogenase; glucose dehydrogenase; ionic liquid; organic solvent; oxidoreductase; two phase system;

D O I：

10.1080/10242420410001692769

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review discusses recent achievements in the field of cofactor regeneration for the nicotinamide cofactors NADH and NADPH. The examples discussed include alcohol dehydrogenases, formate dehydrogenase, glucose dehydrogenase and a hydrogenase. For the reaction either one-phase systems or two-phase systems in combination with an organic solvent are discussed. For the enantioselective reduction of 2-octanone to ( R )-2-octanol it could be shown that enzyme coupled NADPH regeneration with glucose dehydrogenase and glucose results in shorter reaction times and higher yields when compared to the substrate coupled regeneration with 2-propanol.

引用

收藏

页码：89 / 96

页数：8

相关论文

共 52 条

[11] Membrane aerated hydrogenation:: Enzymatic and chemical homogeneous catalysis [J].

Greiner, L ;

Müller, DH ;

van den Ban, ECD ;

Wöltinger, J ;

Wandrey, C ;

Liese, A .

ADVANCED SYNTHESIS & CATALYSIS, 2003, 345 (6-7) :679-683

[12]

GRIENGL H, 2000, BIOCATALYSIS

[13] Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media [J].

Gröger, H ;

Hummel, W ;

Buchholz, S ;

Drauz, K ;

Nguyen, TV ;

Rollmann, C ;

Hüsken, H ;

Abokitse, K .

ORGANIC LETTERS, 2003, 5 (02) :173-176

[14] New continuous production process for enantiopure (2R,5R)-hexanediol [J].

Haberland, J ;

Hummel, W ;

Daussmann, T ;

Liese, A .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2002, 6 (04) :458-462

[15] Diastereoselective synthesis of optically active (2R,5R)-hexanediol [J].

Haberland, J ;

Kriegesmann, A ;

Wolfram, E ;

Hummel, W ;

Liese, A .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2002, 58 (05) :595-599

[16] THERMODYNAMIC PREDICTIONS FOR BIOCATALYSIS IN NONCONVENTIONAL MEDIA - THEORY, TESTS, AND RECOMMENDATIONS FOR EXPERIMENTAL-DESIGN AND ANALYSIS [J].

HALLING, PJ .

ENZYME AND MICROBIAL TECHNOLOGY, 1994, 16 (03) :178-206

[17] BIOCATALYSIS IN MULTIPHASE REACTION MIXTURES CONTAINING ORGANIC LIQUIDS [J].

HALLING, PJ .

BIOTECHNOLOGY ADVANCES, 1987, 5 (01) :47-84

[18] Experimental and theoretical analysis of phase equilibria in a two-phase system used for biocatalytic esterifications [J].

Heinemann, M ;

Kümmel, A ;

Giesen, R ;

Ansorge-Schumacher, MB ;

Büchs, J .

BIOCATALYSIS AND BIOTRANSFORMATION, 2003, 21 (03) :115-121

[19] Immobilized baker's yeast reduction of ketones in an ionic liquid, [bmim]PF6 and water mix [J].

Howarth, J ;

James, P ;

Dai, JF .

TETRAHEDRON LETTERS, 2001, 42 (42) :7517-7519

[20] Towards a large-scale asymmetric reduction process with isolated enzymes:: Expression of an (S)-alcohol dehydrogenase in E-coli and studies on the synthetic potential of this biocatalyst [J].

Hummel, W ;

Abokitse, K ;

Drauz, K ;

Rollmann, C ;

Gröger, H .

ADVANCED SYNTHESIS & CATALYSIS, 2003, 345 (1-2) :153-159

← 1 2 3 4 5 6 →