Syntheses of alkylated malonates on a traceless linker derived soluble polymer support

被引：41

作者：

Zhao, XY ^{[1
]}

Janda, KD ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(97)01216-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new traceless soluble polymeric linker and a corresponding alkylating strategy has been developed. Dimethyl malonate was alkylated with a variety of polymeric halides and these resulting polymer bound malonates underwent further alkylation with additional monoalkyl halides. The methodology described should provide access to libraries of dialkyl malonates. (C) 1997 Elsevier Science Ltd.

引用

页码：5437 / 5440

页数：4

共 5 条

[1] A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports [J].