A window to the heart: can zebrafish mutants help us understand heart disease in humans?

被引：45

作者：

Sehnert, AJ

Stainier, DYR

机构：

[1] Univ Calif San Francisco, Dept Pediat, Div Pediat Cardiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, Program Dev Biol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, Genet Program, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Biochem & Biophys, Program Human Genet, San Francisco, CA 94143 USA

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 10期

关键词：

D O I：

10.1016/S0168-9525(02)02766-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Heart disease is a leading cause of death in the developed world. Abnormalities of heart muscle (cardiomyopathies) and/or electrical conduction (arrhythmias) are frequent causes of heart failure and sudden death. During the past twelve years, identification of genetic mutations that cause familial cardiomyopathies and arrhythmias has fueled a massive increase in molecular investigation into these diseases. Today, studies of zebrafish mutants with defective heart function are providing insight into the genes required to generate a normal heartbeat.

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收藏

页码：491 / 494

页数：4

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